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Preclinical findings Ng and colleagues at Monash University reported in Hormone Research (2000) that obese Zucker rats given AOD9604 orally at 500 µg/kg daily for 19 days gained less than half the body weight of controls (15.8 ± 0.6 g versus 35.6 ± 0.8 g), with increased lipolytic activity measured in adipose tissue