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Common MTHFR Genetic Mutations C677T Heterozygous +/- 30-40% reduction in MTHF production Homozygous +/+ 70-75% reduction in MTHF production A1298C Heterozygous +/- 10-20% reduction in MTHF production Homozygous +/+ 30-40% reduction in MTHF production Compound Heterozygous (C677T/A1298C) 40-60% reduction in MTHF production (Heterozygous one normal gene, one affected gene) (Homozygous one gene from mom, one gene from dad) MTHFR and MORE: METHYLATION BIOMARKERS Within the folate cycle is the gene MTHFR

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