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Although rare, adverse effects of high-dose vitamin B12 have been reported, including allergic reactions such as fever, rash, itching, hot flushes, dizziness, and nausea, across all cobalamin forms and administration routes (Caballero et al., 2007)
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wherein successful direction of mouse and human iPSC-derived dopamine progenitors into SN-like neurons by using WNT inhibitors or SOX6 expression was reported [82]