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This condition encompasses acute mountain sickness (AMS), high-altitude cerebral edema (HACE), and high-altitude pulmonary edema (HAPE), and can also exacerbate pre-existing cardiopulmonary disorders ( Epidemiological studies have shown that approximately 25%–40% of unacclimatized individuals ascending above 2,500 m develop AMS, with a subset progressing to severe forms such as HAPE or HACE ( Current therapeutic strategies include descent to lower altitudes, oxygen supplementation, and administration of pharmacologic agents such as acetazolamide, ibuprofen, dexamethasone, phosphodiesterase type 5 (PDE5) inhibitors (e.g., tadalafil, sildenafil), and β-adrenergic receptor agonists (e.g., salmeterol) ( Stem cells, defined by their self-renewal and multilineage differentiation capacities, are generally classified into embryonic stem cells, adult stem cells (including mesenchymal stem cells (MSCs) and neural stem cells (NSCs)), and induced pluripotent stem cells (iPSCs) based on their origin and differentiation potential (Table 1)
