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Analysis was conducted using an LC-MS QTRAP 6500+ system (SCIEX) equipped with a BEH C18 column (2.1 mm × 10 cm, 1.7 μm, Waters) and operated in ESI+ or ESI− mode

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In this review, we present the efficacy and safety data for the pipeline of obesity pharmacotherapies with a focus on entero-pancreatic hormone-based treatments and we consider the clinical implications and challenges that the new era in obesity management may bring