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These macrophage-derived metabolic signals synergistically increase lipid peroxidation through the ACSL4-dependent synthesis of PUFA-phospholipids, pushing cancer cells beyond their antioxidant capacity and into a state of ferroptosis

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In the TME, immune cells often prioritize glucose uptake, leading to the upregulation of various Gln transporters in different cancer types, including TNBC, esophageal cancer, stomach cancer, and lung cancer

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