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Indeed, early studies have found that hydrochlorothiazide has the potential to influence various facets of glucose homeostasis, spanning from insulin secretion in the islets to the production of glucose in the liver and kidneys under diverse physiopathological conditions in humans and animal models

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That gap is worth planning around: the beyond-use window of a reconstituted solution (covered in the storage section) can be shorter than the drug supply lasts, especially for the 10 mg vial, so re-order and reconstitution-volume decisions should be made against the shorter of the two limits — the stability window or the drug supply — not just the drug supply alone