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Antihistamines come in several forms, usually to help deliver the medication closer to the source of the reaction or make it easier to consume, such as: oral pills dissolvable tablets nasal sprays liquids eye drops Second-generation antihistamines, including Claritin (loratadine) and Zyrtec (cetirizine), are less likely to cause drowsiness than first-generation antihistamines, such as Benadryl