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However, this is considered an underestimation as it will be unlikely to be detected in smaller clinical trials, and a more recent study in 2010 found that NSAIDs including ibuprofen (odds ratio of 2.24, 95% confidence interval (CI) = 1.99–2.52) increased the risk of hospitalization due to acute hepatitis (odds ratio 2.13, 95% CI = 2–2.18) 35

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The identification of reduced cellular glutathione levels and deficient glutathione synthetase activity established this disorder as a unique entity