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1 Background Metabolic reprogramming is a hallmark of malignant tumors ( Glutamine (Gln) metabolic reprogramming is a crucial aspect of tumor metabolic reprogramming and plays a significant role in the initiation and progression of tumors

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For instance, a study by Grace et al., on lambs receiving a single 2 mg subcutaneous B12 injection demonstrated significant increases in serum and liver B12 concentrations for up to 24 days compared to untreated animals (2)