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Moreover, active efflux transporters, such as breast cancer resistance protein (BCRP), P-glycoprotein (P-gp), and multidrug resistance-associated proteins (MRPs), expel many therapeutic agents from the endothelial cells back into the bloodstream, significantly reducing their CNS infiltration 69,70

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➤ Improved Insulin Sensitivity and Glucose Metabolism When NAD⁺ levels rise and fat mass drops, cells become more responsive to insulin

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