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It reported 28.7% average weight loss at 12 mg and 26.4% at 9 mg, compared with 2.1% for placebo

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The first step in creatine synthesis involves the reversible transfer of the amidino group of arginine to glycine to form guanidinoacetic acid (GAA) and ornithine in a reaction catalysed by the enzyme l-arginine:glycine amidinotransferase in the kidneys