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3.4 Evidence Base Neuropathy Trials : RCTs in diabetic neuropathy show 1,500–3,000 mcg methylcobalamin daily improves nerve conduction velocities by up to 20% over 12 weeks

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In fact, cobalamin deficiency is a common cause of metabolic encephalopathy, one of a number of forms of encephalopathy associated with a primary disease (such as FIP) that causes interference with normal brain function and blood-brain barrier mechanisms