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Notably, PPARγ alone is not sufficient to restore redox homeostasis and promote the M2 phenotype, as demonstrated by the exacerbation of neuroinflammatory cytokine production in NRF2-deficient mice challenged with LPS (Innamorato et al., 2008)

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Excellent outcome defined as a mRS of 0-1 at 90 days post stroke and survival were considered as the primary outcome parameters, and symptomatic intracerebral hemorrhage (sICH) was the primary safety parameter