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Perhaps, not surprisingly, sulforaphane is most abundant in the sprouts of cruciferous vegetables, where it facilitates survival and development into mature plants ( In mammals, sulforaphane can similarly upregulate stress-induced signaling pathways, including the Nuclear Factor Erythroid 2-related Factor 2 (NRF2) transcriptional pathway, which is conserved across mammalian species, but absent from plants (Gacesa et al., 2016