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[DOI] [PubMed] [Google Scholar] 367.Grieger J.A., Grzeskowiak L.E., Wilson R.L., Bianco-Miotto T., Leemaqz S.Y., Jankovic-Karasoulos T., Perkins A.V., Norman R.J., Dekker G.A., Roberts C.T

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The rationale for pairing it with GLP-1 is that the GLP-1 (and, for retatrutide, GIP) component is expected to offset the glycaemic effect, leaving the parts of glucagon signalling that researchers are interested in — increased energy expenditure and effects on hepatic lipid handling, including reduced hepatic fat synthesis and increased hepatic lipolysis