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For example, combining immune checkpoint inhibitors, antioxidants, and microbiota-based therapies could strengthen calves’ resistance ( 2.3 Role of inflammatory response and oxidative stress in diarrhea Inflammation and oxidative stress are central to how diarrhea damages the gut: Pro-inflammatory cytokines : diarrheic calves exhibit elevated levels of TNF- α , IL-1β, IL-6, IL-8, and IFN- γ in blood and gut tissue ( E