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For instance, microRNA-375-3p has been shown to alleviate salicylate-induced neuronal injury in vitro by targeting ELAVL4 and subsequently modulating NR2B expression and ROS production, pointing to potential upstream targets for intervention (Zhu et al., 2024)

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While tirzepatide is not primarily eliminated through the kidneys, the gastrointestinal effects of the medication, including potential nausea, vomiting, and diarrhea, could lead to dehydration and electrolyte imbalances that may be particularly problematic in patients with compromised kidney function